Thy1 promoter neurons
Webb19 apr. 2024 · 003709 B6.Cg-Tg(Thy1-YFP)16Jrs/J These thy1-YFP-16 transgenic mice express yellow fluorescent protein at high levels in motor and sensory neurons, as well as in subsets of central neurons. This line provides a strong and specific vital marker for axons, and expression is strong from a mid-gestational stage into adulthood. WebbContains 6.5 kb of the murine thy1.2 gene, extending from the promoter to the intron following exon 4, but lacking exon 3 and its flanking introns (see Figure 1 in Caroni …
Thy1 promoter neurons
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Webb12 apr. 2024 · In parallel to the MOVES-PD trial, we had tested venglustat as a potential benchmark in a mouse model with overexpression of human wild-type (WT) α-synuclein under the murine Thy-1 promoter (Thy1-aSyn mice, Masliah-line 61). 18-20 Thy1-aSyn mice recapitulate key features of PD, such as α-synuclein pathology, dopamine loss, … WebbOne-Stop Solution for Inducing iPS Differentiation into Neurons; Latest Advancements. Current Therapeutic Targets for Alzheimer's Disease; Research Highlights. A Brainwide Atlas of Synapses Across the Mouse Life Span; A Circadian Rhythm-Gated Subcortical Pathway for Nighttime-Light-Induced Depressive-Like Behaviors in Mice
WebbHighly-motivated senior scientist with fourteen years of experience in cellular and molecular neuroscience • Experienced in coordinating collaborative interdisciplinary projects using in vivo as well as 2D and 3D in vitro assays, supervising postdocs, PhD students and laboratory technicians • Trained in designing experiments, testing … WebbNeuron specific mouse thy1 promoter has been used to drive brain specific forced expression of proteins e.g. mutated Amyloid precursor protein (APP) as transgenic animal models of Alzheimer’s disease. … Thy-1 is only expressed on thymocytes in rats (contrast to thymocytes and splenocytes in mice). What CD45 1? Description.
Webb20 feb. 2024 · The Multicolor Cre reporter or Rosa26 Rainbow mouse is a simplified cytoplasmic version of the Brainbow-1.1 mouse in which the neuronal promoter is changed for a CAG promoter and the sequence of FP is switched from mKO, membrane-targeted mCherry, membrane-targeted EYFP and membrane-targeted mCerulean to EGFP, … Webb6 apr. 2024 · We had previously shown that THY1 (CD90) is a tumor suppressor in nasopharyngeal carcinoma (NPC) and that its down-regulation and loss of expression are associated with tumor metastasis, yet the mechanism leading to such effects remains unknown. In this study we show that tumor invasion could be suppressed by THY1 via …
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Webb10 juni 2011 · In SLICK-H mice, the Thy1 promoter drives robust and relatively uniform expression of a drug-inducible form of cre recombinase throughout the peripheral and central nervous system. This permits efficient induction of cre-mediated genetic manipulation upon tamoxifen administration in adult mice. florida sawfish hotlineWebb18 okt. 2012 · To generate GCaMP transgenic mice, we used the well-characterized Thy1 promoter to express GCaMPs in neurons. We generated eight founder lines of GCaMP2.2c and six founder lines of GCaMP3. Our previous studies have shown that the Thy1 promoter predominantly drives transgene expression in projection neurons in the CNS. florida sbdc at hillsborough countyWebbEnter the email address you signed up with and we'll email you a reset link. florida saving for collegeWebb18 mars 2024 · Calcium imaging is commonly used to measure the neural activity of large groups of neurons in mice. Genetically encoded calcium indicators (GECIs) can be delivered for this purpose using non-invasive genetic methods. Compared to viral gene transfer, transgenic targeting of GECIs provides stable long-term expression and … great white boats seat coversWebbOptogenetics is a biological technique to control the activity of neurons or other cell types with light. This is achieved by expression of light-sensitive ion channels, pumps or enzymes specifically in the target cells. On the level of individual cells, light-activated enzymes and transcription factors allow precise control of biochemical signaling pathways. great white boatWebb24 sep. 2014 · Thy1 transgenics can exhibit transgene expression in specific subsets of cortical projection neurons . In GP5.3 mice L2, but not L3 cells, were labeled over large parts of the cortex; in the neocortex of … great white body partsWebbThe encoded prot ein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein … florida sbdc at university of central florida