WebMar 22, 2024 · It binds not only to ergosterol in fungal cell walls but also to cholesterol in human cell membranes; this is what accounts for its nephrotoxicity. Characteristic electrolyte abnormalities include wasting of potassium and magnesium secondary to increased permeability of the cell membranes. WebStatins should be used with caution in patients at increased risk of muscle toxicity, such as the elderly, those with a personal or family history of muscular disorders, history of muscular toxicity or unexplained persistent muscle pain, history of liver disease, a high alcohol intake, known genetic polymorphisms—consult product literature, renal …
Statins for Non-Dialysis Chronic Kidney Disease AAFP
WebKeywords acute kidney injury, drug, nephrotoxicity, pharmacovigilance database AIMS Acute kidney injury (AKI) is associated with a high hospitalization rate, accelerated long-term decline in kidney function and a high mortality rate. Adverse drug reactions (ADRs) constitute one of the most important modifiable factors in the context of AKI. Most WebMay 3, 2013 · There does seem to be some evidence suggesting that people who are on a statin and tolerating it, who then have a fibrate added, may have a problem with creatinine concentration, suggesting that maybe—not definitely, but perhaps—there is some increased risk associated with being on both medicines at the same time. hydroceles form in what potential space
Pharmacology behind Common Drug Nephrotoxicities - PMC
WebStatins include atorvastatin (Lipitor), fluvastatin (Lescol XL), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor, Ezallor) and … WebStatins’ Nephrotoxic Effects Statins generally have few adverse effects; however, they can cause myotoxicity in some patients, leading to muscle breakdown. According to a systematic review published by Ganga, Slim and Thompson (2014), about 10-25% of patients treated with statins in clinical practice develop muscle problems. WebNephrotoxic drugs are pharmacotherapies that can lead to a decline in renal function. The drug may need to be discontinued, or the dosing reduced when this happens. Common … mass dmf fisherman lookup