Phis-peg
Webb14 apr. 2015 · Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery. by Zilan Zhou, Apurva Badkas, Max Stevenson, Joo-Youp Lee, Yuet-Kin Leung. International journal of pharmaceutics. Read more related scholarly scientific articles and abstracts. WebbSuch Mn-ICG@pHis-PEG/GA under a mild NIR-triggered heating is able to induce effective apoptosis of tumor cells, realizing low-temperature PTT (~43 °C) with excellent tumor destruction efficacy. This work not only develops a facile approach to fabricate PEGylated 1D-NCPs with tumor-specific pH responsiveness and theranostic functionalities, ...
Phis-peg
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WebbPHIS/FA/PM showed significant inhibitory effect with a TIR of 85.97%, which was 1.44- and 1.57-fold of PTX-VE and Taxol, respectively. Therefore, it can be concluded that drug … WebbPreparation of M-NP-Gnb nanomicelles The pHis-PEG was synthesized by a ring opening polymerization process. Poly(L-histidine) was conjugated with PEG via an amide bond.In the case of PLGA-PEG-NH 2, PEG-diamine was reacted with PLGA-NHS and the resulting product was reacted with mannose.The mannosylation was performed by ring opening …
WebbPDPA and the PHis, hydrogen bonding between the PEG and PHis backbone, and π-π stacking of the imidazole rings of PHis side chains at physiological pH (pH ~7.4). Synergistic charge-switchable and enzymatic degradation properties of PDPA and PHis make these particles responsive to pH and enzymes. In vitro WebbThe pathways of LHRH-PEG-PHIS-Dox/Dox-TAT micelles entering into tumor cells. Materials and methods Materials Poly (L-histidine) (PHIS) with a number average molecular weight of 15,000 Da (as verified by gel-permeation chromatography) was purchased from Sigma Chemical Co. NHS-polyethylene glycol-COOH (NHS-PEG-COOH; …
Webb20 juni 2015 · A tri-block copolymer, PLGA- b -PHis- b -PEG-azide, was synthesized by conjugating PLGA-COOH to H 2 N-PHis- b -PEG-N 3. As shown in Fig. 1, Boc-His (DNP) … WebbOverall, FMCNPs are promising as a biocompatible and highly efficient coordinated supramolecular nanomedicine for cancer theranostic applications. Recently, …
WebbFinally, PEG-Phis copolymers were synthesized by deprotecting the DNP group of PEG-Phis-DNP with 2-mercaptoethanol. The structure of PEG-Phis was confirmed by using 1 H nuclear magnetic resonance spectroscopy (1 H-NMR, Supplementary Material: Figure S2) (400MHz, DMSO-d 6).
Webb15 aug. 2012 · To overcome the limitations of monomeric pH probes for acidic tumor environments, this study designed a mixed micelle pH probe composed of polyethylene glycol (PEG)-b- poly(L-histidine) (PHis) and PEG-b-poly(L-lactic acid) (PLLA), which is well-known as an effective antitumor drug carrier.Unlike monomeric histidine and PHis … sanford law officeWebb15 apr. 2015 · A dual functional nano-scaled drug carrier, comprising of a targeting ligand and pH sensitivity, has been made in order to increase the specificity and efficacy of the … short cycling boiler after radiator changeWebb10 okt. 2024 · Based on the characteristics of the tumor microenvironment, TMPM formed by synthesized functional copolymers PCL-PEG-PHIS and folate-PEG-PHIS was … sanford lake michigan todayWebbA transformation system for the ringworm-producing dermatophyte Trichophyton mentagrophytes has been developed. The system employs the plasmid pHIS, which contains a bacterial hygromycin B phosphotransferase gene linked to Cochliobolus heterostrophus regulatory sequences (B. G. Turgeon, R. C. Garber, and O. C. Yoder, Mol. … sanford lake michiganWebbThe synthesis scheme of PHIS-PEG 2000 and 7pep-DSPE-PEG 2000 is illustrated in Figure 1A. The PHIS-PEG 2000 was synthesized via a reaction between the amine group of the … sanford landing apartments floridaWebb1 mars 2014 · The dual thermo- and pH-responsive properties of the PHis-PLGA-PEG-PLGA-PHis copolymers as well as their potential for the delivery of anticancer drugs have not been investigated to date. In addition, the copolymer featured a large proportion of hydrophobic blocks (PLGA and PHis) in its molecular structure, which could enable good … sanford lawWebbPurpose: A new approach to monitor drug release and image inflammatory reactions in vitro and in vivo based on FRET mechanism was reported. Methods: In this study, mixed micelles containing a... short cycling