Kidney cancer model zebrafish
WebZebrafish are increasingly used, as they are genetically tractable and have a basic renal anatomy comparable to mammalian kidneys with glomerular filtration and tubular … Web7 mei 2024 · Thus, the Zebrafish model has the advantage of a researcher to follow in real-time the fish’s development from its embryogenesis to full organ development which is reached about 36 h after fertilization. This allows for a vaccine’s effect on all the major organs precursors to be closely studied [ 53] such as using immunohistology (Fig. 2 ). Fig. 2
Kidney cancer model zebrafish
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Web10 feb. 2024 · In conclusion, these results suggest that the adult zebrafish has (1) similar nephrotoxic response to those of mammals, (2) considerable feasibility as an experimental model for toxicity studies, and (3) applicability to pathological examination and genomic biomarker evaluation in drug-induced kidney injury. WebKey facts. The use of zebrafish (Danio rerio) as a model organism began in the 1960s.The zebrafish is a tropical fish native to southeast Asia. The zebrafish is about 2.5 cm to 4 cm long. In its larval stages it is transparent and as it matures to an adult it develops stripes that run along the length of the body and look blue in colour.
Web10 jun. 2024 · With the aim of challenging zebrafish xenografts as an in vivo screening platform for bevacizumab responses, we used several representative tumor cell models of triple negative breast cancer (TNBC ... Web1 apr. 2002 · We propose that the zebrafish is an ideal vertebrate system in which to model cancer. Despite the more than 300 million years separating the last common ancestor of fish and humans, the biology of cancer is very much the same in these two organisms. Cancer is commonly seen in fish in the wild, and straightforward assays involving water …
WebThe kidneys are a pair of kidney bean-shaped organs, located above the waist on either side of the spine, that filter and clean blood and produce urine. The most common adult … WebKidney cancer has three main types. Renal cell cancer, or renal cell adenocarcinoma, forms in the tubules of the kidney. Transitional cell carcinoma forms in the renal pelvis …
Web1 jan. 2005 · Polycystic kidney disease. ... It is possible to model cancer in the zebrafish using various transgenic fish. So far, there are excellent models of leukaemia and melanoma in the zebrafish 20,34,35.
Web15 mei 2024 · Acute Kidney Injury Model Induced By Cisplatin In Adult Zebrafish - Video. JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles. JoVE is the world-leading producer and provider of science videos with the mission to improve … gary song from spongebobWeb14 jan. 2024 · To uncover the relationship between skin bacterial flora and pathogen infection, we developed a percutaneous infection model using zebrafish and Yersinia ruckeri, a pathogen causing enteric redmouth disease in salmon and in trout. Pathogen challenge, either alone or together with pricking by a small needle, did not cause … garys opticWeb9 aug. 2016 · In addition to utilizing zebrafish disease models to characterize human diseases, researchers can also identify and test new drugs to treat the diseases being … gary sonic videosWeb14 apr. 2024 · Mutation of the ataxia-telangiectasia mutated (atm) gene in humans and mice renders them susceptible to tumors due to both its role as a DNA damage sensor acting in pre-malignant cells to activate Tp53 and to its role in sensing and reducing oxidative stress.The oncogene UHRF1 is overexpressed in many cancers and we previously … gary sonsWeb1 jan. 2010 · The zebrafish is conducive to large-scale forward genetic screens, which have generated models of a variety of human diseases. This chapter reviews the achievements of the zebrafish in modeling human disease including cancer, hematopoietic disorders, and cardiovascular disease. It surveys approaches that are available to zebrafish … gary sorrentino zoomWeb1 mei 2008 · As already mentioned, chemical treatment of both embryos and adult animals is relatively easy for zebrafish. In this respect, zebrafish can be a versatile model in the … gary soto biography for kidsWeb13 apr. 2024 · Ion-channel-regulated bioelectric signals have emerged as a player of the patterning mechanism, which may interact with morphogens. Evidence from multiple model organisms reveals the roles of bioelectricity in embryonic development, regeneration, and cancers. The Zebrafish model is the second most used vertebrate model, next to the … garyson perry