Hipec cisplatin sodium thiosulfate
Webb11 mars 2024 · First, the authors did not detail cisplatin-related adverse events (AEs) completely. Second, all patients received sodium thiosulphate during the procedure of HIPEC to alleviate cisplatin-related nephrotoxicity, so the real nephrotoxicity induced by hyperthermic cisplatin remains unclear.
Hipec cisplatin sodium thiosulfate
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Webb14 juli 2024 · Remarkably, clinical evidence for strategies to prevent cisplatin-induced AKI is scarce. Van Driel et al., who did not observe significant nephrotoxicity in a collective of 118 patients treated with cisplatin HIPEC, routinely applied administered sodium thiosulphate (9 g/m 2) to prevent nephrotoxicity. Webb2 maj 2024 · Objectives: Cisplatin is commonly used during intraperitoneal …
Webb25 apr. 2024 · Objectives: - To determine intraperitoneal (IP) progression free survival … WebbSodium thiosulfate is a neutralizing agent for cisplatin that protects against renal …
WebbImproved survival from childhood cancer has been achieved at the cost of long-term comorbidities that reduce quality of life. The chemotherapy agent cisplatin is essential for treatment of many paediatric and adolescent malignancies but in a large proportion of patients results in cisplatin-induced hearing loss, a debilitating and permanent late … WebbCisplatin (CDDP) is one of the most frequently used drugs for peritoneal infusion. A …
Webb1 jan. 2024 · Cisplatin (CDDP) is one of the most frequently used drugs for peritoneal infusion. A major restriction is that CDDP causes renal toxicity and acute renal failure, sometimes leading to chronic renal failure. The aim of the present study was to assess the impact of sodium thiosulfate (ST) in preventing renal impairment (RI) following HIPEC …
WebbCisplatin is commonly used during intraperitoneal chemotherapy however has well-established nephrotoxic side-effects. Sodium thiosulfate is often added to cisplatin-based hyperthermic intraperitoneal chemotherapy (HIPEC) protocols to mitigate this, however evidence regarding risk of hypernatraemia is scarce as of yet. Methods mariah way off lewis turner boulevardWebb26 maj 2024 · The renal toxicity associated with cisplatin HIPEC and major abdominal surgery can be minimised with careful preoperative optimisation, intra operative fluid management and attention to renal function. The addition of sodium thiosulphate is a safe and effective method to minimise toxicity and should … mariah wheatley facebookWebb15 feb. 2024 · The IV perfusion of sodium thiosulfate is for renal protection. At the start … mariah west car accidentWebb5 maj 2024 · HIPEC was performed with a cisplatin solution (50 mg/m2) at 41°C. The median age of the patients was 56 years (range: 32–74 years), the median peritoneal cancer index (PCI) was 13 (range: 4–21), the median operation time was 356 minutes (range: 192–507 minutes). The median time to postoperative systemic treatment with … natural foods hair growthWebbtherapy (HIPEC) with cisplatin has been shown to improve overall sur- vival in … mariah wedding sister wivesWebbHIPEC was administered at the end of the cytoreductive surgical procedure with the use … natural foods grocery store near meWebbPrior to HIPEC infusion, surgical teams must communicate with anesthesia and pharmacy. In patients receiving HIPEC with cisplatin, furosemide and mannitol should be administered one hour prior to chemotherapy to ensure adequate diuresis. Sodium thiosulfate may also be considered for renal protection (van Driel et al., n.d. [3]). natural foods grocery store