WebMay 14, 2024 · cholinesterase (koh-lin-est-er-ayz) n. an enzyme that breaks down a choline ester into its choline and acid components. The term usually refers to …
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WebJan 19, 2024 · Acetylcholinesterase (AChE) is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately … The term cholinesterase is sometimes used to refer specifically to butyrylcholinesterase, but this usage produces the oddity that cholinesterase and false cholinesterase (pseudocholinesterase) under that scheme mean the same thing (confusingly), and acetylcholinesterase is then called true … See more The enzyme cholinesterase (EC 3.1.1.8, choline esterase; systematic name acylcholine acylhydrolase) catalyses the hydrolysis of choline-based esters: an acylcholine + H2O = choline + a carboxylate See more The two types of cholinesterase are acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE). The difference between … See more An absence or mutation of the BCHE enzyme leads to a medical condition known as pseudocholinesterase deficiency. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants succinylcholine See more • Acetylcholine • Choline • Acetic acid • Butyrylcholine See more In 1968, Walo Leuzinger et al. successfully purified and crystallized acetylcholinesterase from electric eels at Columbia … See more A cholinesterase inhibitor (or "anticholinesterase") suppresses the action of the enzyme. Because of its essential function, chemicals that interfere with the action of cholinesterase are potent neurotoxins, causing excessive salivation and eye … See more • ATSDR Case Studies in Environmental Medicine: Cholinesterase Inhibitors, Including Insecticides and Chemical Warfare Nerve Agents U.S. Department of Health and Human Services • Movies at weizmann.ac.il showing the structure of acetylcholinesterase … See more phenylephrine guaifenesin dextromethorphan
Part 2: What are cholinesterase inhibitors? - Agency for Toxic ...
WebAcetylcholinesterase Inhibitor. AChE inhibitor (generally referred to as cholinesterase inhibitor) is a chemical that binds to the enzyme, cholinesterase, and prevents it from breaking down the neurotransmitter, ACh. With toxic doses, the result is that excessive levels of the ACh build up in the synapses and neuromuscular junctions and glands. WebButyrylcholinesterase (BChE) is an enzyme responsible for metabolizing succinylcholine (Fig. 1). Patients who are deficient in BChE are at risk of prolonged neuromuscular blockade and apnea. Deficiency in BChE is largely due to mutations in the BCHE gene. Weba·ce·tyl·cho·lin·es·ter·ase ( a-sĕ'til-kō'lin-es'ter-ās ), [MIM*100740] The cholinesterase that hydrolyzes acetylcholine to acetate and choline within the central nervous system and at … phenylephrine hci 5mg